The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using a covalent tethering approach to identify inhibitors preferentially targeting the inactive conformation.
申请公布号
WO03081210(A2)
申请公布日期
2003.10.02
申请号
WO2003US08725
申请日期
2003.03.20
申请人
SUNESIS PHARMACEUTICALS, INC.;PRESCOTT, JOHN, C.;BRAISTED, ANDREW