NUCLEIC ACID MOLECULES INVOLVED IN THE SYNTHESIS OF MELITHIAZOLS

摘要

The present invention relates to the isolation and characterization of novel polyketide synthase and nonribosomal peptide synthetase genes from the myxobacterium Melittangium lichenicola Me I 46 that are necessary for the biosynthesis of melithiazols. Further, the present invention relates to methods of improving the pharmacological properties of melithiazols by biocombinatorial methods. The invention also relates to such improved melithiazols as well as to pharmaceutical compositions comprising such improved melithiazols.