PROSTAGLANDIN F2alpha ANALOGS AND THEIR USE IN COMBINATION WITH ANTIMICROBIAL PROTEINS FOR THE TREATMENT OF GLAUCOMA AND INTRAOCULAR HYPERTENSION

摘要

An ophthalmic formulation for the treatment of glaucoma and intraocular pressure with a prostaglandin compound of the F-series (PGF), and particularly a prodrug form of a PGF2alpha analog, such as an ester, amide, or internal lactone, wherein the preservative is an antimicrobial peptide, such as lactoferrin. In particularly preferred embodiments, the prostaglandin compound is a macrocyclic internal 1,15-lactone, such as the 16-aryloxy prostaglandin analogs, illustratively fluprostenol or cloprostenol.