DECOMPOSITION INHIBITOR FOR EXTRACELLULAR MATRIX OF CARTILAGE

摘要

A medicinal composition which contains a compound represented by the general formula (I): (I) wherein R<1> is hydroxy, etc.; R<2> is optionally substituted lower alkyl, etc.; R<3> is hydrogen, etc.; R<4> is optionally substituted allylene, etc.; R<5> is a single bond, -C=C-, etc.; and R<6> is optionally substituted aryl, etc.), an optically active isomer thereof, a prodrug thereof, a pharmaceutically acceptable salt of any of these, or a solvate of any of these. It has decomposition inhibitory activity against the extracellular matrix of a cartilage.