PHOSPHATE TRANSPORT INHIBITORS

摘要

Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I). R1 and R2 are independently -H, an electron withdrawing group or a C1-C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or -CR1R2P(O)(OH)-. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from -C1, -Br, -F, -CN, -NO2, -OR, -N(R)2, -COOR, -CON(R)2, -COR, -S(O)R, -S(O)2R, -S(O)2N(R)2, -NRS(O)2R, -NRCOR, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each R is independently -H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently -H, a lower alkyl group, or a phosphate protecting group.