| 摘要 |
A compound of the formula: (I) and-physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR.3; X2 is N or CR'4; X3 ,is..N or CR5; X4 is N or CR6 with the proviso that at least one but not more than two of X1, X 2, X,3. and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d formula: (II) wherein X5 is a group selected from N or CR7: and X6, is a group selected from O, S or NR8; X7 and X8; which maybe the same or, different is a group selected from N or CR9; ; X9, is a group selected from O, S or NR8 and X10 is N or CR10 ; X11 , X12 and X13 may be the same or different and selected from a group N or <CR>11 ; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
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| 申请人 |
GLAXO GROUP LIMITED;BAILEY, NICHOLAS;BAMFORD, MARK, JAMES;GARLAND, STEPHEN;GOODMAN, KRISTA, B.;HAIFENG, CUI;HILFIKER, MARK, A.;LEE, DENNIS;PANCHAL, TERENCE, AARON;STAVENGER, ROBERT, A.;WILSON, DAVID, MATTHEW;WITHERINGTON, JASON |
发明人 |
BAILEY, NICHOLAS;BAMFORD, MARK, JAMES;GARLAND, STEPHEN;GOODMAN, KRISTA, B.;HAIFENG, CUI;HILFIKER, MARK, A.;LEE, DENNIS;PANCHAL, TERENCE, AARON;STAVENGER, ROBERT, A.;WILSON, DAVID, MATTHEW;WITHERINGTON, JASON |
