| 发明名称 |
TNF-derived peptides for use in treating oedema |
| 摘要 |
The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-alpha) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-alpha from Ser<100 >to Glu<116 >to treat pulmonary oedema. For example, the circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC is shown to be very efficient in inducing oedema resorption.
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| 申请公布号 |
US2003185791(A1) |
申请公布日期 |
2003.10.02 |
| 申请号 |
US20020162553 |
申请日期 |
2002.06.06 |
| 申请人 |
LUCAS RUDOLF;BAETSELIER PATRICK DE;PUGIN JEROME;BLOC ALAIN;FRANSEN LUCIE |
发明人 |
LUCAS RUDOLF;BAETSELIER PATRICK DE;PUGIN JEROME;BLOC ALAIN;FRANSEN LUCIE |
| 分类号 |
A61K38/00;A61K;A61K38/19;A61P;A61P3/00;A61P7/10;A61P11/00;A61P43/00;C07K;C07K7/06;C07K7/08;C07K14/525;(IPC1-7):A61K38/19;A61K38/12 |
主分类号 |
A61K38/00 |
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