Short peptides and derivatives or analogs thereof for the treatment or prevention of transmissible spongiform encephalopathies, in particular CJD are herein described. These peptides and/or their derivatives have been designed to block the conformational changes that occur in the prion protein (PrP) and which are implicated in the pathogenesis of transmissible spongiform encephalopathies as well as to dissolve the fibrillar deposits already formed
申请公布号
WO03050139(A3)
申请公布日期
2003.10.02
申请号
WO2002EP13915
申请日期
2002.12.09
申请人
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.;ADESSI, CELINE;HALAZY, SERGE;SABORIO, GABRIELA;SOTO-JARA, CLAUDIO