PROCESS FOR THE PREPARATION OF 4-OXYTETRAHYDROPYRAN-2-ONES
摘要
A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mixture thereof or without solvents. It is characteristic of this reaction that no additional impurities are obtained and that it takes place without the use of additional catalysts and with low excesses of the reagent.
申请公布号
WO03080591(A1)
申请公布日期
2003.10.02
申请号
WO2003SI00009
申请日期
2003.03.17
申请人
KRKA TOVARNA ZDRAVIL, D.D., NOVO MESTO;ZUPANCIC, SILVO;KRASOVEC, DUSAN;ZUPET, PAVEL