PROTEIN KINASE C MODULATORS, THEIR AMINOACID AND NUCLEOTIDE SEQUENCES AND USES THEREOF

摘要

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides capable of modulating the Protein Kinase C activity for therapeutic, diagnostic and research purposes. The polypeptides according to the invention bind Protein Kinase C when this is in an activated form. According to preferred embodiments such polypeptides correspond to SEQ ID NO 2, 4, 5, 7, 9, 11, 12, 13. The invention also provides for the nucleotidic sequence encoding for the polypeptides disclosed, preferably such polynucleotide corresponds to SEQ ID NO 1, 3, 6, 8, 10.