Preparation process of pure form (II) 1-isopropyl-3-¬(4-M toluidino-3-pyridyl) sulphonyl -urea (Torasemide) and pharmaceutical preparations thereof

摘要

The present invention concerns the use of 1-isopropyl-3-Ä(4-m-toluidino-3-pyridyl)sulphonylÜ-urea in the pharmaceutical field. In particular, it proposes the use of a pure and stable polymorphic form of 1-isopropyl-3-Ä(4-m-toluidino-3-pyridyl)sulphonylÜ-urea for the preparation of solid pharmaceutical forms, and likewise a method of synthesis to obtain such a pure and stable polymorphic form of 1-isopropyl-3-Ä(4-m-toluidino-3-pyridiyl)sulphonylÜ-urea.