METHOD OF PREPARING PHARMACEUTICAL DOSAGE FORMS CONTAINING MULTIPLE ACTIVE INGREDIENTS

摘要

A method for the preparation of pharmaceutical dosage forms comprising multiple powdered active ingredients, in a preferred embodiment, said method comprising the steps of mixing said active ingredients and at least one chosen excipient so as to obtain a powdered mixture; compacting said powdered mixture in a roller-compactor apparatus to obtain a compacted product; breaking and sieving said compacted product to a chosen mesh size to obtain similar sized granules; preferably dry mixing said granules with a t least on chosen excipient so as to obtain a granular mixture; forming said granular mixture into unitary dosage forms.