| 摘要 |
The invention relates to an amide compound with formula wherein Rc' is selectively substituted heterocycle possessing nitrogen, which is other than pyridine; Rb is hydrogen, alkyl, aralkyl, aminoalkyl or mono- or dialkylaminoalkyl; R5 is hydrogen, hydroxy, alkoxy, alkoxycarbonyloxy, alkanoyloxy or aralkyloxycarbonyloxy; L is hydrogen, alkyl, aminoalkyl, mono- or dialkylaminoalkyl, tetrahydrofurfuryl, carbamoylalkyl, phthalimidoalkyl, amidino or a group with formula or wherein B is hydrogen, alkyl, alkoxy, aralkyl, aralkyloxy, aminoalkyl, hydroxyalkyl, alkanoyloxyalkyl, alkoxycarbonylalkyl, alpha-aminobenzyl, furyl, pyridyl, phenyl, phenylamino, styryl or imidazopyridyl, Q1 is hydrogen, halogen, hydroxy, aralkyloxy or thienylmethyl , W is alkylene, Q2 is hydrogen, halogen, hydroxy or aralkyloxy, X is alkylene, Q3 is hydrogen, halogen, hydroxy, alkoxy, nitro, amino, 2,3-dihydrofyryl or 5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine-6-yl; and Y is a single bond, alkylene or alkenylene. The invention also relates to an isomer of the said compound, and/or its pharmaceutically acceptable salt, produced by the addition of acid, salt and to its application as Rho kinase inhibitor. 13 claims
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