CELL-SPECIFIC RETROVIRAL VECTORS WITH ANTIBODY DOMAINS AND METHOD FOR THE PRODUCTION THEREOF FOR SELECTIVE GENE TRANSFER

摘要

The invention relates to cell- specific retroviral vectors with antibody domains (scFv), which are suitable for cell-specific transduction of a selected mammal cell type (cell targeting). The invention also relates to a method for the production of cell-specific retroviral vectors and to the use thereof in gene transfers in selected cells. The invention further relates to retroviral packaging cells to obtain inventive cell-specific retroviral vectors.