| 摘要 |
<p>PURPOSE: Provided are cephalosporin compounds and a preparation method thereof, which compounds have antimicrobial activity to the wide range of gram positive bacteria. CONSTITUTION: Cephalosporin compounds represented by formula (1), pharmaceutically acceptable nontoxic salts thereof, physiologically hydrolyzable esters, hydrides, solvates and isomers thereof are provided, wherein A is hydrogen or amino protecting group; R1 is hydrogen, one to three oxygen or halogen C1-6 alkyl, C3-4 alkenyl, one nitrogen containing C3-4 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkyl-methyl or one to two nitrogen or oxygen containing C5-6 heteroarylmethyl; R2 is hydrogen or carboxyl protecting group; V is N or C; W is C, N or N+-U, in which W is C when V is N, and W is N or N+-U when V is C; U is C1-5 alkyl or amino; Y is hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkyl substituted or unsubstituted amino, C1-6 hydroxyalkyl or C1-6 alkylthio; Z is a compound of I and J; I is S, SO or SO2; n is 1, 2, 3 or 4; J is C1-6 alkyl substituted or unsubstituted amino, hydroxy or substituted C1-6 alkoxy; Q is CH, CX' or N; and X' is halogen.</p> |
