AMIDES OF ACETIC AND PROPIONIC ACIDS

摘要

1-Azabicycloalkyl-substituted acetic or propionic acid N-(heteroaryl, naphthyl or azulenyl)-amides (I) are new. Azabicycloalkyl-alkanamides of formula R1-A-CO-NR2R3 (I) and their salts, solvates and solvated salts are new. R1 = aza-bicyclo (m.n.p) alkyl with 7-11 ring atoms (optionally substituted by T); T = 1-6C alkyl; m, n = 2 or 3; p = 1-3; A = CH2 or CH2CH2; R2 = 8-10 membered heteroaryl, naphthyl or azulenyl, all optionally substituted by halo, CHO, CONR4R5, COOR6, NR7R8, NR9COR10, CN, CF3, OCF3, NO2, T', OT' or ST'; T' = T (optionally substituted by OH, NH2, NHCOR11 or CN); R4-R11 = H, T, phenyl or benzyl; R3 = H or T. An Independent claim is also included for the preparation of (I).