| 摘要 |
PURPOSE: An inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activities is provided which inhibits cholesterol synthesis and accumulation in body tissues. Therefore, it is used in the prevention and treatment of cardiovascular disease. CONSTITUTION: An inhibitor of HMG-CoA reductase contains isoflavones as an effective ingredient. The isoflavones are separated from fermented soybean paste(toenjang). The isoflavones are selected from the group consisting of genistein, daidzein, glycitein, daidzin, genistin, glycitin, 6'-0-acetyl-genistin, 6'-0-acetyl-daidzin, 6'-0-acetyl-glycitin, 6'-0-malonyl-genistin, 6'-0-malonyl-daidzin and 6'-0-malonyl-glycitin. Preferably daily dosage of isoflavones is in the range of 1 and 25mg/day.
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