Benzocycloheptene derivatives, pharmaceuticals thereof and their use for producing medicaments

摘要

Benzocycloheptenes having selective estrogenic activity on bones, which are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis of formula (I) wherein: R1 and R2 independently are hydrogen, hydroxy, optionally substituted alkoxy, optionally substituted alkanoyloxy or an optionally substituted aroyloxy; and SK is a side chain -A-B-Z, where A is a direct bond or an oxygen atom, B is a straight- or branched-chain optionally substituted alkylene, alkenylene or alkinylene group with up to 10 carbon atoms, Z is a group -D-SOx-E-G, an amino group -NR7R8 or a substituent G. The compounds can also have antiestrogenic activity, which can be detected in an anti-uterus growth test, or in tumor models.