| 摘要 |
A transgenic mouse whose somatic and germ cells have a substantial deficiency in the corticotropin releasing factor receptor-1, wherein one or both alleles of the corticotropin releasing factor receptor-1 are disrupted resulting in a mouse with decreased anxiety, reduced endocrine response to stress and altered locomoter activity rhythms as compared to a control mouse. Also covered are methods of using said mouse for identifying agonists and antagonists of corticotropin releasing factor, urocortin or related ligands that act through receptors other than corticotropin releasing factor receptor-1, offspring from said mouse, using offspring from said mouse to screen compounds that are analogs of corticosterone or corticotropin and a method of producing said transgenic mouse.
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