发明名称 |
POLYMERS FOR DELIVERING NITRIC OXIDE IN VIVO |
摘要 |
Disclosed are novel polymers derivatized with at least one -SNO group per 12 00 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polym er has stabilized -S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by structural formul a (1). R is an organic radical. Each X' is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each X' is the same and is a C2-C6 alkylene group, more preferably -CH2-, -CH2CH2-, -CH2CH2CH2- or - CH2CH2CH2CH2-. pand m are independently a positive integer such that p + m i s greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites. |
申请公布号 |
CA2336138(A1) |
申请公布日期 |
1999.12.29 |
申请号 |
CA19992336138 |
申请日期 |
1999.06.17 |
申请人 |
DUKE UNIVERSITY MEDICAL CENTER |
发明人 |
STACK, RICHARD S.;TOONE, ERIC J.;STAMLER, JONATHAN S. |
分类号 |
A61L27/00;A61K31/785;A61K47/48;A61L29/00;A61L31/10;A61L31/16;A61L33/00;A61L33/06;A61L33/08;C08B37/00;C08B37/16;C08G75/00;C08G75/14;(IPC1-7):C08B37/00 |
主分类号 |
A61L27/00 |
代理机构 |
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