发明名称 |
New human apical iodide transporter useful for screening of compounds able to modulate apical iodide transport in cells for treatment, prevention or diagnosis of dysfunctional iodide transport |
摘要 |
Isolated, purified protein (I) comprising a fully defined sequence of 610 amino acids (S2) or a sequence at least 70-99 % similar to (S2) over its entire length, where the sequence AAH 17691 of the NCBI database is specifically exclude, is new. Independent claims are also included for: (1) a peptide fragment (Ia) of (I) containing at least 7 amino acids (aa); (2) isolated nucleic acid (II) that encodes (I), and its sense and antisense complements; (3) probe or primer (III) containing at least 8 base pairs (bp) of (II) but excluding AI261687, AI433656, AI793005 and AW195079 of GenBank and BC017691 of NCBI; (4) a recombinant vector that contains (II) or (III); (5) a cell transformed with the vector of (4); (6) antibodies (Ab) directed against (I) or (Ia); (7) a transgenic non-human mammal that contains cells transformed with (II); (8) screening for compounds able to modulate apical iodide transport in cells; (9) detecting a mutation in the AIT (apical iodide transporter) gene; and (10) a kit for the screening and detection methods.
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申请公布号 |
FR2837492(A1) |
申请公布日期 |
2003.09.26 |
申请号 |
FR20020003572 |
申请日期 |
2002.03.21 |
申请人 |
COMMISSARIAT A L'ENERGIE ATOMIQUE |
发明人 |
LEBLANC GERARD;POURCHER THIERRY |
分类号 |
A61K38/00;A61P5/00;C07K14/705;C12N15/12;(IPC1-7):C07K14/47;C07K7/06;C07K16/18;C12N15/63;C07H21/00;C12Q1/68;A01K67/027;G01N33/53;A61K39/395;A61K31/711;A61K31/710;A61K48/00;A61K38/08;A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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