发明名称 |
Mice that are homozygously deficient in CRFR2 and uses thereof in drug screening |
摘要 |
Disclosed are transgenic mice deficient in corticotropin releasing factor receptor 2 (CRFR2). CRFR2 mutant mice are hypersensitive to stress, and display increased anxiety-like behavior. The mice have homozygous defective CRFR2 genes, and exhibit a phenotype of increased anxiety behavior, a hypersensitive hypothalamic-pituitary- adrenal (HPA) axis response to stress and a muted cardiovascular response to urocortin administration. Such knockout mice are useful for screening compounds for anxiety modulating activity, blood pressure control and effect on the response of the hypothalamic-pituitary- adrenal (HPA) axis to stress.
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申请公布号 |
NZ516611(A) |
申请公布日期 |
2003.09.26 |
申请号 |
NZ20000516611 |
申请日期 |
2000.07.14 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
LEE, KUO-FEN;BALE, TRACY L;SMITH, GEORGE W;VALE,WYLIE |
分类号 |
A01K67/027;A61K38/00;C07K14/72;C12N15/85;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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地址 |
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