| 摘要 |
A group of 2-position substituted imidazole compounds of formula (I), methods for producing said compounds and their use in treating p38 (CSBP) mediated diseases, wherein: X is oxygen, CH2, sulfur, or NH, or the moiety X-R1 is hydrogen; V is CH; R1 is hydrogen, alkyl, aryl, aryl-alkyl, heterocyclic, heterocyclylc alkyl, heteroaryl, or heteroaryl-alkyl, wherein each of these moieties may be optionally substituted; X1 is hydrogen, XR1, optionally substituted alkyl, halogen, hydroxy, optionally substituted alkoxy, optionally substituted alkylthio, optionally substituted alkylsulfinyl, CH2OR12, amino, mono and di- alkyl substituted amino, N(R10)C(O)Rb, N(RIO)S(O)2Rd, or an N-heterocyclyl ring which ring has from 5 to 7 members and optionally contains an additional heteroatom selected from oxygen, sulfur or NR15 ; R2 is independently an optionally substituted alkyl, and wherein the two R2 moieties may together form a cycloalkyl or cycloalkenyl ring which ring may be optionally substituted; Y is alkenyl, hydroxy substituted alkyl, heterocyclic, or N (R10)C(Z)R3; Z is oxygen or sulfur; Ar is an aryl or heteroaryl ring which ring may be optionally substituted.
|
