| 摘要 |
The present invention provides reagents and methods for identifying inhibito rs of the L-type Ca2+ channel .beta.3 protein, which has been demonstrated to b e involved in calcium signaling, insulin secretion, and glucose homeostasis. T he invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca2+ channel .beta.3 subunit to provide a benefit to the subject. |
