MOUSE lambda LIGHT CHAIN LOCUS

摘要

The present invention provides in a first aspect a mouse in which the lambda (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse lambda light chain locus was functional silenced by deletion of gene segments coding for the lambda light chain locus. In a further aspect, a mouse containing functionally silenced lambda and kappa (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.