| 摘要 |
A pharmaceutical composition which contains (i) a complex of (a) one or more OCIF substances selected from the group consisting of an osteoclastogenesis inhibitory factor, an analog thereof and a variant thereof, and (b) a polysaccharide substance comprising a polysaccharide or a derivative thereof and (ii) a substance suppressing production of a prostaglandin and/or a substance competing an action of a prostaglandin. The invention also provides a method for treatment or prevention of a bone metabolic disease by administering to a patient in need thereof, an effective amount of (i) a complex of (a) one or more OCIF substances selected from the group consisting of an osteoclastogenesis inhibitory factor, an analog thereof and a variant thereof, and (b) a polysaccharide substance comprising a polysaccharide or a derivative thereof, and of (ii) a substance suppressing production of prostaglandin and/or a substance competing an action of prostaglandin.
|
