| 发明名称 |
Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
| 摘要 |
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R1-R3, X, and A-D are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
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| 申请公布号 |
US2003181388(A1) |
申请公布日期 |
2003.09.25 |
| 申请号 |
US20030434335 |
申请日期 |
2003.05.09 |
| 申请人 |
CYTOVIA, INC. |
发明人 |
CAI SUI XIONG;WANG YAN;WEBER ECKARD;MILLS GORDON B.;GREEN DOUGLAS R. |
| 分类号 |
C12N9/99;A61K9/02;A61K9/06;A61K9/08;A61K9/22;A61K31/27;A61K31/381;A61K38/00;A61P1/00;A61P1/02;A61P1/04;A61P1/16;A61P1/18;A61P3/10;A61P7/00;A61P7/06;A61P9/00;A61P13/10;A61P13/12;A61P15/08;A61P17/00;A61P17/02;A61P17/06;A61P17/14;A61P17/16;A61P19/02;A61P19/08;A61P25/00;A61P25/32;A61P27/02;A61P29/00;A61P37/00;A61P39/00;A61P43/00;C07C271/22;C07C271/24;C07C271/28;C07D333/38;C07D333/40;C07K5/023;C07K7/02;C12N5/04;C12N5/06;(IPC1-7):A61K38/08;A61K38/06;A61K38/05;C07K7/06;C07K5/06;C07K5/04 |
主分类号 |
C12N9/99 |
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