INHIBITION OF THE beta3 SUBUNIT OF L-TYPE CA<2+> CHANNELS

摘要

The present invention provides reagents and methods for identifying inhibitors of the L-type Ca<2+> channel beta3 protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca<2+> channel beta3 subunit to provide a benefit to the subject.