| 摘要 |
<p>The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by <i>Lawsonia intracellularis</i> or similar or otherwise related microorganisms. In particular, the present invention provides a novel gene derived from <i>Lawsonia intracellularis</i>, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity against <i>Lawsonia intracellularis</i> and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting <i>Lawsonia intracellularis</i> or similar or otherwise related microorganisms.</p> |
