AMINOMETHYL-SUBSTITUTED THIAZOLOBENZIMIDAZOLE DERIVATIVE

摘要

A novel aminomethyl-substituted thiazolobenzimidazole derivative represented by the following general formula (I) or a salt thereof. The derivative or salt has metabotropic glutamate receptor activity, has excellent oral activity, and is useful as a medicine. (I) (In the formula, R<1> represents oxygenic saturated heterocycle, etc.; Alk1 represents lower alkylene; m is 0 or 1; Alk2 represents lower alkylene optionally substituted by oxo; n is 0 or 1; X represents a bond, oxygen, sulfur, or NR<5>; R<3> represents hydrogen, etc.; and R<2>, R<4>, R<5>, R<6>, and R<7> are the same or different and each represents hydrogen, etc.; provided that when X is a bond and n is 1, then R<3> represents neither lower alkyl nor lower halogenoalkyl, and when m is 1, R<1> is OH or OMe, Alk1 is C1-3 alkylene, and either 1) X is a bond, n is 1, and R<3> is hydrogen or 2) X is a bond, n is 0, and R<3> is cyclohexane, then R<4> represents a group other than Me.)