发明名称 |
HISTONE DEACETYLASE INHIBITORS IN DIAGNOSIS AND TREATMENT OF THYROID NEOPLASMS |
摘要 |
Disclosed herein are novel approaches to thyroid cancer therapy. These approaches include methods to enhance thyroid specific gene expression, for example methods to enhance expression of thyroglobulin and/or the Na<+>/I<-> symporter in thyroid cancer cells. Enhanced expression of thyroid-specific genes promotes cellular differentiation and reduces biologically aggressive behavior such as invasion and metastasis. In addition, enhanced expression of thyroglobulin and/or the Na<+>/I<-> symporter increases the ability of thyroid cancer cells to concentrate iodine or iodide, thereby making the cells more susceptible to radioactive iodine therapy. Also disclosed herein are methods for detecting thyroid neoplasms in a subject, by administering a therapeutically effective amount of a histone deacetylase inhibitor, administering a detectable agent whose uptake or concentration in thyroid cells is increased by administration of the histone deacetylase inhibitor, and detecting the detectable agent.
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申请公布号 |
WO02055688(A8) |
申请公布日期 |
2003.09.25 |
申请号 |
WO2002US00714 |
申请日期 |
2002.01.09 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES;FOJO, ANTONIO, TITO;BATES, SUSAN, ELAINE |
发明人 |
FOJO, ANTONIO, TITO;BATES, SUSAN, ELAINE |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K38/15;A61K45/00;A61K51/00;A61K51/02;A61P5/14;A61P35/00;A61P35/04;A61P43/00;C07K14/705;C07K14/71;C12N15/113;(IPC1-7):C12Q1/25 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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