BENZENE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF

摘要

Novel benzene derivatives represented by the general formula (||), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (||) wherein R<1>, R<4> and R<6> are each independently hydrogen, halogeno, or hydrocarbyl; R<2> is hydrocarbyl or a heterocyclic group; R<3> is hydrocarbyl, NR<7'>R<7>, or OR<8> (wherein R<7'> is hydrogen or hydrocarbyl and R<7> is a non-aromatic group, or alternatively R<7' >and R<7> together with the nitrogen atom adjacent thereto may form a ring; and R<8> is hydrocarbyl or a heterocyclic group); R<5> is hydrocarbyl or a heterocyclic group (except quinolyl) and R<5'> is hydrogen or hydrocarbyl, or R<5> and R<5'> together with the nitrogen atom adjacent thereto may form a ring; and R<5''> is hydrogen or hydrocarbyl.