PHARMACEUTICAL COMPOSITIONS COMPRISING MANNOSE BINDING LECTIN

摘要

The present invention relates to pharmaceutical compositions comprising MBL and/or MBL variants. In particular the invention relates to pharmaceutical compositions comprising at least 200 µg/ml protein containing material, wherein mannan binding lectin (MBL) and/or MBL variants constitutes at least 35% (w/w) of the total protein; or to compositions comprising at least 400 µg/ml mannan binding lectin (MBL) and/or MBL variants. In addition the invention relates to pharmaceutical com-positions comprising MBL and/or MBL variants and divalent cations. The invention also describes methods of preparing said compositions. The pharmaceutical compositions according to the invention may for example be used in methods of treatment of a number of different clinical conditions including infections. Uses of the compositions for preparation of medicaments for treatment of a clinical condition are also described.