PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES

摘要

A process for formation of N-aryl piperazines with chiral side-chains having the structure shown in formula below, and for making intermediate compounds therefor: (Formula I). In this process, chirality is introduced at the piperazine ring formation step and 2-aminopyridyl substitution is incorporated via displacement. The resulting N,N'-disubstituted piperazines act on the central nervous system at 5HT receptors.