CELL SURFACE TROPOMYOSIN AS A TARGET OF ANGIOGENESIS INHIBITION

摘要

The present invention is directed to novel methods for inhibiting angiogenes is and treating tumors and cancer by targeting tropomyosin (Tpm) expressed on t he surface of endothelial cells and/or tumor cells, to Tpm polypeptides and peptides, as well as variants and derivatives thereof that bind inhibitors o f angiogenesis, and to anti-Tpm antibodies that block or stimulate angiogenesi s. Cyclic peptides that bind to the D5 subunit of HKa and inhibit angiogenesis are also included. Method for screening test compounds as candidate antiangiogenic molecule that binds to Tpm are disclosed, as are affinity ligands comprising the proteins, peptides, variants and derivatives of the invention.