发明名称 |
Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
摘要 |
The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present inventin can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.
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申请公布号 |
US2003181723(A1) |
申请公布日期 |
2003.09.25 |
申请号 |
US20030382185 |
申请日期 |
2003.03.04 |
申请人 |
AEROJET FINE CHEMICALS LLC, A DELAWARE LIMITED LIABILITY COMPANY |
发明人 |
MALIK ASLAM A.;PALANDOKEN HASAN;STRINGER JOY A.;CARLSON ROLAND P.;LEACH JOHN;ARCHIBALD THOMAS G.;MIOTKE ROBERT G. |
分类号 |
C07C269/06;C07C271/20;C07C303/40;C07C311/18;(IPC1-7):C07D217/18;C07C243/18 |
主分类号 |
C07C269/06 |
代理机构 |
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