| 发明名称 |
Oligonucleotide analogs having modified dimers |
| 摘要 |
Modified dimers having a ribose sugar moiety in the 5' nucleoside and a 2' modified sugar in the 3' nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.
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| 申请公布号 |
US2003181693(A1) |
申请公布日期 |
2003.09.25 |
| 申请号 |
US20020195211 |
申请日期 |
2002.07.15 |
| 申请人 |
COOK PHILLIP DAN;MANOHARAN MUTHIAH;BHAT BALKRISHEN |
发明人 |
COOK PHILLIP DAN;MANOHARAN MUTHIAH;BHAT BALKRISHEN |
| 分类号 |
C07H21/00;C12N15/113;C12Q1/68;(IPC1-7):C07H21/04;C07H19/22;C07H19/048 |
主分类号 |
C07H21/00 |
| 代理机构 |
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| 主权项 |
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