发明名称 |
METHOD FOR MAKING CARTILAGE AND IMPLANTS |
摘要 |
<p>Cartilage tissue and implants comprising cartilage tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space (1) and are left in this cell space for producing an extracellular cartilage matrix. The cells are brought into the cell space to have a cell density of ca. 5x107 to 109 cells per cm3 of cell space. The cell space (1) is at least partly separated from a culture medium space (2) surrounding the cell space by a semi-permeable wall (3) or by an open-pore wall acting as convection barrier. The open-pore wall can be designed as a plate (7) made of a bone substitute material and constituting the bottom of the cell space (1). The cells settle on such a plate (7) and the cartilage tissue growing in the cell space (1) grows into pores or surface roughness of the plate, whereby an implant forms which consists of a bone substitute plate (7) and a cartilage layer covering the plate and whereby the two implant parts are connected to each other in positively engaged manner by being grown together.</p> |
申请公布号 |
EP0922093(B1) |
申请公布日期 |
2003.09.24 |
申请号 |
EP19970922797 |
申请日期 |
1997.06.02 |
申请人 |
SULZER ORTHOPEDICS LTD. |
发明人 |
RIESER, FRANZ;MUELLER, WERNER;BITTMANN, PEDRO;MAINIL-VARLET, PIERRE;SAAGER, CHRISTOPH, P. |
分类号 |
A61B17/68;A61F2/00;A61F2/28;A61F2/30;A61K35/12;A61L27/00;A61L27/38;C12M3/06;C12N5/077;(IPC1-7):C12N5/06;C12N5/08 |
主分类号 |
A61B17/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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