| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain an active-form DESC1 protein of true structure having activity, to provide a method for screening a medicine for inhibiting inflammation accentuation action, intracellular calcium inflow causing action, PAR activation action and plasminogen activator activation action caused by mucus production accentuation action, EGFR route activation action, cytokinin production accentuation, etc., by the active-form DESC1 protein and to construct an evaluation system for detecting the activity. <P>SOLUTION: The DESC1 has structure in which a propeptide part represented by a specific amino acid sequence is bonded through a disulfide bond to a trypsin-like protein part. The inhibitor has the mucus production accentuation action, PAR activation action, the intracellular calcium inflow causing action, IL-8 production enhancement action or cell growth promotion action of an enzyme having the structure as an index. The screening system of inhibitory polypeptide is provided. The antibody is bonded to the enzyme having the structure. <P>COPYRIGHT: (C)2003,JPO |
