摘要 |
Methods of synthesizing pure enantiomers of acylanalides such as Casodex(R) (bicalutamide) and its derivatives utilizing a compound having a ring structure that, when opened, provides a substituent having the structure of Formula I: wherein R<SUP>1 </SUP>is alkyl or haloalkyl having up to 4 carbons; R<SUP>2 </SUP>is alkyl having up to 6 carbon atoms; and R<SUP>3 </SUP>is CH<SUB>2</SUB>OR<SUP>4 </SUP>where R<SUP>4 </SUP>is hydrogen or benzyl, C(O)CH<SUB>3</SUB>, or C(O)OR<SUP>5 </SUP>where R<SUP>5 </SUP>is hydrogen or alkyl; are disclosed. |