摘要 |
Novel compounds that either preferentially absorb into hyperproliferative tissue and absorb light efficiently at a wavelength of between about 700 and about 850 nm or act as intermediates for such absorbing compounds. More particularly, the compounds of the invention have the formula:where R<1>, R<5>, R<9>, and R<10 >are independently lower alkyl of 1 to 3 carbon atoms provided that at least three of R<1>, R<5>, R<9>, and R<10 >are methyl; R<2 >is -OH, -OR<11>, -NHR<11>, aryl, or -aminoacid; R<3 >and R<4 >are independently -COR<11 >or taken together areR<6 >and R<7 >are independently lower alkyl of 1 to 3 carbon atoms; R<8 >is O-alkyl of 1 to about 12 carbon atoms, S-alkyl of 1 to about 12 carbon atoms, -O-aryl, or -O-heterocyclic ring of 5 or 6 carbon atoms; R<11 >is alkyl of 1 to 6 carbon atoms; and R<12 >is lower alkyl of 1 to about 12 carbon atoms, aryl, or aminoalkyl of 1 to 8 carbon atoms; provided that at least one of R<8>, R<11>, and R<12 >is hydrophobic and together contain at least 10 carbon atoms. The invention also includes method of making and using the compounds.
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