发明名称 |
Inhibition of human telomerase by a G-quadruplex-interaction compound |
摘要 |
Certain non-nucleoside compounds that will selectively inhibit telomerase by targeting the nucleic add structures, such as G-quadruplexes, that may be associated with human telomeres or telomerase have been identified. Inhibition of human telomerase by two perylenetetracarboxylic acid diimides and a carbocyanine has been demonstrated. <1>H-NMR studies have evidenced the stabilization of a G-quadruplex by the perylenetetracarboxylic acid diimide compounds and provided evidence that these and structurally related compounds inhibit the telomerase enzyme by a mechanism consistent with interaction with G-quadruplex structures.
|
申请公布号 |
US6623930(B2) |
申请公布日期 |
2003.09.23 |
申请号 |
US20010940173 |
申请日期 |
2001.08.27 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
KERWIN SEAN M.;FEDOROFF OLEG Y.;SALAZAR MIGUEL;HURLEY LAURENCE H. |
分类号 |
C07D277/64;C07D471/06;C12Q1/68;(IPC1-7):C12Q1/68;A61K31/44;C07D21/22 |
主分类号 |
C07D277/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|