发明名称 |
Method of purifying a fermentation broth. |
摘要 |
A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization. |
申请公布号 |
ZA200206496(B) |
申请公布日期 |
2003.09.23 |
申请号 |
ZA20020006496 |
申请日期 |
2002.08.14 |
申请人 |
BIOGAL GYOGYSZERGYAR RT. |
发明人 |
VILMOS KERI;LAJOS DEAK;ILONA FORGACS |
分类号 |
C12P17/06;A61K31/351;A61P9/00;A61P9/10;C07D;C07D309/30;C12N;C12N9/99;C12P;C12P7/62;C12P17/02 |
主分类号 |
C12P17/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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