| 摘要 |
PURPOSE: Provided is a method of preparing sulfinyl benzimidazole derivatives represented by the formula 1 using safe and cheap calcium hypochloride as an oxidant. The synthetic process, using the sulfinyl benzimidazole derivatives, produces anti-tumor drug Lansoprazol and Omeprazole more effectively and economically. CONSTITUTION: A preparation method of preparing sulfinyl benzimidazole derivatives represented by the formula 1 comprises oxidizing sulfide compound represented by the formula 2 in a hydrophilic solvent such as a mixture of water and acetonitrile at 15-30deg.C, wherein the amount of solvent used is 0.4-3.0 moles per mole of compound (2). In the formula 1 and formula 2, R1 is H, OCH3,or NC4H4; R2 is H, CH3 or OCH3; R3 is H or CH3; and R4 is CH3, CH2CF3 or C3H6OCH3.
|
