SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS
摘要
The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.
申请公布号
WO03077062(A2)
申请公布日期
2003.09.18
申请号
WO2003US06491
申请日期
2003.03.05
申请人
TRUSTEES OF BOSTON UNIVERSITY;GARDNER, TIMOTHY, S.;COLLINS, JAMES, J.;DI BERNARDO, DIEGO;TEGNER, JESPER;YEUNG, MAN, KIT, STEPHEN