HETEROCYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF DIABETESAND OTHER DISEASES

摘要

The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4- thiazolidinedione, 2-thioxothiazolidine-4-one, 2,4-imidazolidinedione or 2- thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.