PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF GLYCOSAMINOGLYCANES AND PRODUCTS OBTAINED THEREFROM

摘要

The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers , alcohols, aldehydes, amides and formic acid. The invention also relates to intermediate depolymerized heparin having Mw comprised between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio S03-/COO- equal to or high er than in the starting heparin. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.