NOVEL FUNCTION OF Wnt AND APPLICATION THEREOF TO TREATMENT OF DISEASES

摘要

Drugs containing Wnt protein or a gene encoding Wnt protein and having an effect of promoting insulin secretion or ameliorating lipid metabolism; a method of identifying an agonist to LRP5 and 6; and a method of identifying a compound controlling the expression of Wnt protein and LRP5/6 in cells. The agonist and the compound identified these methods are useful in treating or preventing, in particular, diabetes, hyperlipemia or impaired glucose tolerance, similar to drugs containing Wnt.