| 摘要 |
The present invention relates to the delivery of drugs through an inhalation route. Specifically, it relates to the information of drug thermal vapors from a heated open-celled substrate (106) for use in inhalation therapy. In a method aspect of the present invention, a method of delivering a drug to a mammal through an inhalation route is provided which comprises heating a composition to form a thermal vapor, which is inhaled by the mammal, wherein the composition comprises a drug, and wherein the composition is coated onto a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells. In a device aspect of the present invention, a device for delivering a drug to a mammal through an inhalation route is provided, wherein the device comprises: a power source (108) ; a substrate (106), wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells; and, an element (110) permitting the mammal to inhale the thermal vapor. In a kit aspect of the present invention, a kit for delivering a drug to a mammal through an inhalation route is provided which comprises: a) a composition comprising a drug; and b) a device that forms a drug thermal vapor from the composition for inhalation by the mammal, wherein the device comprises a substrate, and wherein the substrate has a high surface to volume ratio, high porosity, and a three-dimensional network of interconnected cells. |
