The present invention relates to a method of treating or preventing obesity (or suppressing the appetite) in a human patient by antagonizing CB1 receptors and inhibiting the enzyme 11beta-HSD1 in an amount that is effective to treat or prevent obesity. Compounds useful in the present invention have an ion channel activity level greater than about 2 microM. Preferably the compound is a dual selective inhibitor, selectively antagonizing CB1 receptors and selectively inhibiting the enzyme 11beta-HSD1.
申请公布号
WO03075660(A1)
申请公布日期
2003.09.18
申请号
WO2003US06031
申请日期
2003.02.28
申请人
MERCK & CO., INC.;FONG, TUNG, M.;VAN DER PLOEG, LEONARDUS, H., T.